The NorLux vision
The NorLux Neuro-Oncology laboratories will establish a centre of excellence within the field of brain tumour research. NorLux will through state of the art research, build up a critical mass of competitive scientists within the major fields of biomedical research (basic science, translational research towards clinical application). Through identification of new therapeutic targets towards brain cancer and through the design of new treatment strategies, NorLux will be pro-active in the development of biotechnology and through its activities develop and establish close relations to pharmaceutical industry.
To work towards this vision, a strategic agreement has been made between Luxembourg Institute of Health and the Medical Faculty at the University of Bergen to establish the NorLux Laboratories. The key elements of the agreement are:
- Joint research
- Scientific competence building
- Staff exchange
NorLux project objectives
NorLux will identify and validate novel mechanisms responsible for brain tumour initiation, growth and progression. Using unique preclinical animal model systems, combined with large-scale genomics and proteomics technologies, putative therapeutic targets will be identified. NorLux will create effective and tumor-selective therapeutic strategies that complement or substitute established therapies. The overall scientific and coordination objectives are to perform multidisciplinary research efforts of highest international stature within the field of brain tumour biology. This effort includes the following specific objectives:
1. Identify the cellular origin of cancer initiation in brain tumors. Perform a detailed characterization of the identified cells both at genetic and epigenetic levels.
2. Develop novel animal models and preclinical assessment strategies, that as closely as possible reflect human brain tumor growth in situ.
3. To unravel the mechanisms responsible for angiogenesis dependent and angiogenesis independent tumor growth.
4. To develop a comprehensive understanding of the cellular processes responsible for tumour re-growth after therapy.
5. Develop high resolution imaging techniques to study brain tumo