Norlux Neuro-Oncology Laboratory

Organizational chart

Headed by Dr. Simone P. Niclou, the NorLux Neuro-Oncology Laboratory has developed a strong translational research programme on brain cancers to understand the underlying biological mechanisms of malignant gliomas and develop innovative treatment strategies based on clinically relevant animal models. The research focuses on tumor angiogenesis, metabolism, tumour heterogeneity and treatment resistance and applies emerging molecular and cellular approaches, including large scale screens, genomics, proteomics, patient derived animal models and in vivo imaging (MRI & PET). Niclou is also adjunct professor at the Kristian Gerhard Jebsen Brain Tumour Research Centre of the University of Bergen (Norway), with which she has a longstanding scientific partnership.

The laboratory is organized in the following sub-groups:

PI : Simone Niclou, PhD

Translational aspects of brain tumour research, with a focus on tumour angiogenesis, invasion and tumour metabolism.

- Anna Golebiewska, PhD
- Alessandro Michelucci, PhD
- Fred Fack, PhD
- Anne Schuster, PhD
- Virginie Neirinckx, PhD
- Sabrina Fritah, PhD
- Ann-Christin Hau, PhD
- Monika Dieterle, PhD
- Olivier Keunen, PhD
- Georgia Kanli
- Anais Oudin
- Amandine Bernard
- Virginie Baus
- Vanessa Barthelemy
- Andres Cano Galiano 
- Carole Sousa
- Anne Dirkse
- Yolanda Pires Afonso
- Siu Thinh Ho
- Stephanie Sallai
- Chantal Courtois
- Vitor Lopes

PI : Eric Van Dyck, PhD

Beyond their role in preventing genetic instability and tumorigenesis, DNA repair and epigenetic mechanisms also contribute to the resistance of cancer cells to chemotherapeutic genotoxics, and are responsible in great part for the failure of current anti-GBM therapies. Our objectives are to better understand the mechanisms that operate to repair DNA damage induced by chemoradiation in GBMs, and identify critical targets and novel strategies to prevent chemoresistance and tumor relapse.

- Hélène Erasimus
- Matthieu Gobin
- Katrin Neumann

PI : Francisco Azuaje, PhD

Our objective is to develop novel strategies to predict and treat cancer based on a systematic, integrated analysis of multiple “omics” and clinically-relevant data. Our research combines computational, in vitro and in vivo experimental approaches. We put emphasis on the investigation of large biological interaction networks to guide the discovery of disease biomarkers and the selection of effective therapies.

- Sophie Rodius, PhD
- Céline Jeanty
- Leon-Charles Tranchevent