Clinically-relevant animal models for malignant gliomas
Based on the implantation of human glioma spheroids, we have generated patient-derived xenograft (PDX) models in rodents that recapitulate the major characteristics associated with glioblastomas including angiogenesis and tumor invasion.
The glioma xenografts obtained in these animals appear either angiogenic - displaying abnormal blood vessels, and/or highly invasive, depending on the patient's GBMs used for implantation. In addition we have available xenografts of oligodendroglial tumors carrying the IDH1 mutation, which are very rare and difficult to grow in model systems.
These models will greatly facilitate the dissection of the biological mechanisms behind angiogenesis and tumor invasion and represent important tools for clinically relevant therapeutic intervention studies, which is crucial for developing novel treatment paradigms.